5KK7
Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase T688A mutant and Thio-disaccharide substrate analog complex
Summary for 5KK7
| Entry DOI | 10.2210/pdb5kk7/pdb |
| Related PRD ID | PRD_900033 |
| Descriptor | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, alpha-D-mannopyranose-(1-2)-methyl 2-thio-alpha-D-mannopyranoside, CALCIUM ION, ... (8 entities in total) |
| Functional Keywords | alpha/alpha-barrel, cation replacement, protein-glycan interaction, hydrolase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : Q9UKM7 |
| Total number of polymer chains | 2 |
| Total formula weight | 106710.03 |
| Authors | Karaveg, K.,Xiang, Y.,Moremen, K.W. (deposition date: 2016-06-21, release date: 2017-05-10, Last modification date: 2020-07-29) |
| Primary citation | Xiang, Y.,Karaveg, K.,Moremen, K.W. Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc. Natl. Acad. Sci. U.S.A., 113:E7890-E7899, 2016 Cited by PubMed: 27856750DOI: 10.1073/pnas.1611213113 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7324 Å) |
Structure validation
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