5KIJ

Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex

5KIJ の概要

• エントリーDOI: 10.2210/pdb5kij/pdb
• 分子名称: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LANTHANUM (III) ION, ... (7 entities in total)
• 機能のキーワード: alpha/alpha-barrel, cation replacement, protein-glycan interaction, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54441.18

構造登録者

Karaveg, K.,Xiang, Y.,Moremen, K.W. (登録日: 2016-06-16, 公開日: 2017-05-10, 最終更新日: 2023-09-27)

• 主引用文献: Xiang, Y.,Karaveg, K.,Moremen, K.W.; Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.; Proc. Natl. Acad. Sci. U.S.A., 113:E7890-E7899, 2016; PubMed: 27856750; DOI: 10.1073/pnas.1611213113

実験手法

X-RAY DIFFRACTION (1.649 Å)