5KHW

Crystal structure of JAK1 in complex with ADP

Summary for 5KHW

• Entry DOI: 10.2210/pdb5khw/pdb
• Related: 5KHX
• Descriptor: Tyrosine-protein kinase JAK1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: jak1, kinase, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Endomembrane system; Peripheral membrane protein: P23458
• Total number of polymer chains: 2
• Total formula weight: 73737.95

Authors

Han, S.,Caspers, N.L. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2018-04-18)

• Primary citation: Caspers, N.L.,Han, S.,Rajamohan, F.,Hoth, L.R.,Geoghegan, K.F.,Subashi, T.A.,Vazquez, M.L.,Kaila, N.,Cronin, C.N.,Johnson, E.,Kurumbail, R.G.; Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.; Acta Crystallogr F Struct Biol Commun, 72:840-845, 2016; PubMed: 27827355; DOI: 10.1107/S2053230X16016356

Experimental method

X-RAY DIFFRACTION (2.47 Å)