5KHX
Crystal structure of JAK1 in complex with PF-4950736
Summary for 5KHX
Entry DOI | 10.2210/pdb5khx/pdb |
Descriptor | Tyrosine-protein kinase JAK1, ~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide (3 entities in total) |
Functional Keywords | jak1, kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 1 |
Total formula weight | 36712.83 |
Authors | Han, S.,Caspers, N.L. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2018-05-16) |
Primary citation | Caspers, N.L.,Han, S.,Rajamohan, F.,Hoth, L.R.,Geoghegan, K.F.,Subashi, T.A.,Vazquez, M.L.,Kaila, N.,Cronin, C.N.,Johnson, E.,Kurumbail, R.G. Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system. Acta Crystallogr F Struct Biol Commun, 72:840-845, 2016 Cited by PubMed: 27827355DOI: 10.1107/S2053230X16016356 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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