5KH4
Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS) with FARNESYL DIPHOSPHATE
Summary for 5KH4
Entry DOI | 10.2210/pdb5kh4/pdb |
Descriptor | Isoprenyl transferase, FARNESYL DIPHOSPHATE (2 entities in total) |
Functional Keywords | upps, native, bacterial, undecaprenyl s. pneumoniae, transferase |
Biological source | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
Total number of polymer chains | 2 |
Total formula weight | 62587.06 |
Authors | Concha, N.O. (deposition date: 2016-06-14, release date: 2016-07-20, Last modification date: 2024-03-06) |
Primary citation | Concha, N.,Huang, J.,Bai, X.,Benowitz, A.,Brady, P.,Grady, L.C.,Kryn, L.H.,Holmes, D.,Ingraham, K.,Jin, Q.,Pothier Kaushansky, L.,McCloskey, L.,Messer, J.A.,O'Keefe, H.,Patel, A.,Satz, A.L.,Sinnamon, R.H.,Schneck, J.,Skinner, S.R.,Summerfield, J.,Taylor, A.,Taylor, J.D.,Evindar, G.,Stavenger, R.A. Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase. J.Med.Chem., 59:7299-7304, 2016 Cited by PubMed: 27379833DOI: 10.1021/acs.jmedchem.6b00746 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
Download full validation report