5KH4

Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS) with FARNESYL DIPHOSPHATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004659	molecular_function	prenyltransferase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0030145	molecular_function	manganese ion binding
A	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004659	molecular_function	prenyltransferase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
B	0016094	biological_process	polyprenol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0030145	molecular_function	manganese ion binding
B	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue FPP A 301

Chain	Residue
A	ASP28
A	ARG206
A	GLY29
A	ASN30
A	GLY31
A	HIS45
A	ALA71
A	ARG79
A	LEU90
A	PHE143

---

site_id	AC2
Number of Residues	13
Details	binding site for residue FPP B 301

Chain	Residue
B	MET27
B	ASP28
B	GLY29
B	ASN30
B	GLY31
B	ARG32
B	HIS45
B	MET49
B	ALA71
B	ARG79
B	LEU90
B	PHE143
B	LEU145

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Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLIIRTSGelRlSnFLPW

Chain	Residue	Details
A	ASP196-TRP213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---