5KDL

Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS

Summary for 5KDL

Entry DOI	10.2210/pdb5kdl/pdb
Related	5KDO
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (4 entities in total)
Functional Keywords	heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release, signaling protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	82493.80
Authors	Kaya, A.I.,Lokits, A.D.,Gilbert, J.,Iverson, T.M.,Meiler, J.,Hamm, H.E. (deposition date: 2016-06-08, release date: 2016-08-03, Last modification date: 2023-09-27)
Primary citation	Kaya, A.I.,Lokits, A.D.,Gilbert, J.A.,Iverson, T.M.,Meiler, J.,Hamm, H.E. A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor. J.Biol.Chem., 291:19674-19686, 2016 Cited by PubMed: 27462082 DOI: 10.1074/jbc.M116.745513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.665 Å)

Structure validation