5K9R
PDE10a with imidazopyrazine inhibitor
Summary for 5K9R
Entry DOI | 10.2210/pdb5k9r/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 73403.94 |
Authors | |
Primary citation | Meegalla, S.K.,Huang, H.,Illig, C.R.,Parks, D.J.,Chen, J.,Lee, Y.K.,Wilson, K.J.,Patel, S.K.,Cheung, W.S.,Lu, T.,Kirchner, T.,Askari, H.B.,Geisler, J.,Patch, R.J.,Gibbs, A.C.,Rady, B.,Connelly, M.,Player, M.R. Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors. Bioorg.Med.Chem.Lett., 26:4216-4222, 2016 Cited by PubMed: 27491708DOI: 10.1016/j.bmcl.2016.07.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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