5K9R
PDE10a with imidazopyrazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 312 | 36126.7 | 2 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 4-[5-[1-(2-methoxyethyl)pyrazol-4-yl]-2-(quinolin-2-yloxymethyl)imidazo[1,2-a]pyrazin-8-yl]morpholine | non-polymer | 485.5 | 2 | Chemie (6RC) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B: 448 - 759 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 657 | Gly 657 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72253.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1150.5 | |
| All* | Total formula weight | 73403.9 |
