5K9I

Crystal structure of c-SRC in complex with a covalent lysine probe

5K9I の概要

• エントリーDOI: 10.2210/pdb5k9i/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride (3 entities in total)
• 機能のキーワード: covalent lysine probe, transferase
• 由来する生物種: Gallus gallus (Chicken)
• 細胞内の位置: Cell membrane : P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66530.48

構造登録者

Wan, X.,Ouyang, S.,Zhao, Q.,Taunton, J. (登録日: 2016-05-31, 公開日: 2017-02-01)

• 主引用文献: Zhao, Q.,Ouyang, X.,Wan, X.,Gajiwala, K.S.,Kath, J.C.,Jones, L.H.,Burlingame, A.L.,Taunton, J.; Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.; J. Am. Chem. Soc., 139:680-685, 2017; PubMed: 28051857; DOI: 10.1021/jacs.6b08536

実験手法

X-RAY DIFFRACTION (2.5 Å)