5K9D

Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution

5K9D の概要

• エントリーDOI: 10.2210/pdb5k9d/pdb
• 関連するPDBエントリー: 5K9C
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, OROTIC ACID, ... (9 entities in total)
• 機能のキーワード: oxidoreductase, alpha/beta barrel
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41708.59

構造登録者

Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Scadden, D.T.,Rustiguel, J.K.,Nonato, M.C.,Schreiber, S.L. (登録日: 2016-05-31, 公開日: 2016-10-12, 最終更新日: 2023-09-27)

• 主引用文献: Lewis, T.A.,Sykes, D.B.,Law, J.M.,Munoz, B.,Rustiguel, J.K.,Nonato, M.C.,Scadden, D.T.,Schreiber, S.L.; Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.; ACS Med Chem Lett, 7:1112-1117, 2016; PubMed: 27994748; DOI: 10.1021/acsmedchemlett.6b00316

実験手法

X-RAY DIFFRACTION (1.7 Å)