5K8D

Crystal structure of rFVIIIFc

5K8D の概要

• エントリーDOI: 10.2210/pdb5k8d/pdb
• 分子名称: Coagulation factor VIII, Coagulation factor VIII,Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: coagulation factor, factor viii, human igg1 fc domain, hemophilia a, blood clotting
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 186530.06

構造登録者

Leksa, N.,Quan, C. (登録日: 2016-05-29, 公開日: 2017-06-14, 最終更新日: 2023-09-27)

• 主引用文献: Leksa, N.C.,Chiu, P.L.,Bou-Assaf, G.M.,Quan, C.,Liu, Z.,Goodman, A.B.,Chambers, M.G.,Tsutakawa, S.E.,Hammel, M.,Peters, R.T.,Walz, T.,Kulman, J.D.; The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.; J. Thromb. Haemost., 15:1167-1179, 2017; PubMed: 28397397; DOI: 10.1111/jth.13700

実験手法

X-RAY DIFFRACTION (4.19 Å)