5K64

Crystal structure of VEGF binding IgG1-Fc (Fcab 448)

5K64 の概要

• エントリーDOI: 10.2210/pdb5k64/pdb
• 分子名称: Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, vegf, vascular endothelial growth factor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : P01857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53943.01

構造登録者

Humm, A.,Lobner, E.,Kitzmuller, M.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (登録日: 2016-05-24, 公開日: 2017-09-06, 最終更新日: 2024-01-10)

• 主引用文献: Lobner, E.,Humm, A.S.,Mlynek, G.,Kubinger, K.,Kitzmuller, M.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.; MAbs, 9:1088-1104, 2017; PubMed: 28816592; DOI: 10.1080/19420862.2017.1364825

実験手法

X-RAY DIFFRACTION (2.44 Å)