5K3Y

Crystal structure of AuroraB/INCENP in complex with BI 811283

5K3Y の概要

• エントリーDOI: 10.2210/pdb5k3y/pdb
• 分子名称: Aurora kinase B-A, Inner centromere protein A, N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• 細胞内の位置: Nucleus: Q6DE08 O13024
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81388.26

構造登録者

Bader, G.,Zahn, S.K.,Zoephel, A. (登録日: 2016-05-20, 公開日: 2016-08-17, 最終更新日: 2022-12-07)

• 主引用文献: Sini, P.,Gurtler, U.,Zahn, S.K.,Baumann, C.,Rudolph, D.,Baumgartinger, R.,Strauss, E.,Haslinger, C.,Tontsch-Grunt, U.,Waizenegger, I.C.,Solca, F.,Bader, G.,Zoephel, A.,Treu, M.,Reiser, U.,Garin-Chesa, P.,Boehmelt, G.,Kraut, N.,Quant, J.,Adolf, G.R.; Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.; Mol.Cancer Ther., 15:2388-2398, 2016; PubMed: 27496137; DOI: 10.1158/1535-7163.MCT-16-0066

実験手法

X-RAY DIFFRACTION (1.6 Å)