5K32

PDE4D crystal structure in complex with small molecule inhibitor

Summary for 5K32

Entry DOI	10.2210/pdb5k32/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterases, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Apical cell membrane : Q08499
Total number of polymer chains	2
Total formula weight	77695.30
Authors	Segarra, V.,Hernandez, B.,Roberts, R.,Gracia, J.,Soler, M.,Bonin, I.,Aymami, J. (deposition date: 2016-05-19, release date: 2017-03-29, Last modification date: 2024-01-10)
Primary citation	Roberts, R.S.,Sevilla, S.,Ferrer, M.,Taltavull, J.,Hernandez, B.,Segarra, V.,Gracia, J.,Lehner, M.D.,Gavalda, A.,Andres, M.,Cabedo, J.,Vilella, D.,Eichhorn, P.,Calama, E.,Carcasona, C.,Miralpeix, M. 4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships. J. Med. Chem., 61:2472-2489, 2018 Cited by PubMed: 29502405 DOI: 10.1021/acs.jmedchem.7b01751 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation