5K32
PDE4D crystal structure in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 325 | 37419.5 | 2 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | C, V (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, W (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, X (A, B) | 4-[(3-methoxyphenyl)amino]-2-phenyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one | non-polymer | 345.4 | 2 | Chemie (6Q2) | |||
| 5 | AA, BA, CA, DA, EA... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 32 | Chemie (EDO) | |||
| 6 | OA, PA (A, B) | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A, B: 88 - 411 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Ala 87 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74838.9 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 2856.4 | |
| All* | Total formula weight | 77695.3 |
