5JU5

Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 1

Summary for 5JU5

• Entry DOI: 10.2210/pdb5ju5/pdb
• Descriptor: Tankyrase-1 (2 entities in total)
• Functional Keywords: tankyrase polymerisation, wnt signalling, poly(adp-ribose)polymerase (parp), transferase, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 6
• Total formula weight: 53124.35

Authors

Guetter, S.,Mariotti, L.,Cronin, N. (deposition date: 2016-05-10, release date: 2016-08-03, Last modification date: 2024-01-10)

• Primary citation: Mariotti, L.,Templeton, C.M.,Ranes, M.,Paracuellos, P.,Cronin, N.,Beuron, F.,Morris, E.,Guettler, S.; Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.; Mol.Cell, 63:498-513, 2016; PubMed: 27494558; DOI: 10.1016/j.molcel.2016.06.019

Experimental method

X-RAY DIFFRACTION (2.5 Å)