5JSA

Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128

Summary for 5JSA

• Entry DOI: 10.2210/pdb5jsa/pdb
• Related: 5JS9
• Descriptor: broadly neutralizing antibody PGT128 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• Functional Keywords: hiv-1 trimer, ufo, sosip, vaccine, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 180365.45

Authors

Kong, L.,Wilson, I.A. (deposition date: 2016-05-07, release date: 2016-07-13, Last modification date: 2023-09-27)

• Primary citation: Kong, L.,He, L.,de Val, N.,Vora, N.,Morris, C.D.,Azadnia, P.,Sok, D.,Zhou, B.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Zhu, J.; Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.; Nat Commun, 7:12040-12040, 2016; PubMed: 27349805; DOI: 10.1038/ncomms12040

Experimental method

X-RAY DIFFRACTION (6.308 Å)