5JL4
Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
Summary for 5JL4
| Entry DOI | 10.2210/pdb5jl4/pdb |
| Descriptor | Integrase, SULFATE ION (3 entities in total) |
| Functional Keywords | allini hiv integrase multimerization, dna binding protein |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 36287.37 |
| Authors | Feng, L.,Kobe, M.,Kvaratskhelia, M. (deposition date: 2016-04-26, release date: 2017-10-04, Last modification date: 2023-09-27) |
| Primary citation | Hoyte, A.C.,Jamin, A.V.,Koneru, P.C.,Kobe, M.J.,Larue, R.C.,Fuchs, J.R.,Engelman, A.N.,Kvaratskhelia, M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J. Biol. Chem., 292:19814-19825, 2017 Cited by PubMed: 28972144DOI: 10.1074/jbc.M117.816645 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.758 Å) |
Structure validation
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