5JL4
Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 163 | 17951.6 | 2 | UniProt (D0ENR2) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, F (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 212 (UniProt: D0ENR2)
| PDB | External Database | Details |
|---|---|---|
| Ile 165 | Val 165 | engineered mutation |
| Ile 174 | Thr 174 | engineered mutation |
| Lys 185 | Phe 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35903.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 36287.4 |
