5JKK
Crystal structure of the negatively supercharged variant Ftn(neg) of human heavy chain ferritin
Summary for 5JKK
| Entry DOI | 10.2210/pdb5jkk/pdb |
| Descriptor | Ferritin heavy chain, FE (III) ION, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | protein design, protein engineering, charged protein containers, binary protein structures, self-assembly, binary nanoparticle superlattices, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 8 |
| Total formula weight | 171886.93 |
| Authors | Kuenzle, M.,Beck, T. (deposition date: 2016-04-26, release date: 2017-05-10, Last modification date: 2024-01-10) |
| Primary citation | Kunzle, M.,Eckert, T.,Beck, T. Metal-Assisted Assembly of Protein Containers Loaded with Inorganic Nanoparticles. Inorg.Chem., 57:13431-13436, 2018 Cited by PubMed Abstract: Protein containers are suitable building blocks for bioinorganic materials. Here, we show that high concentrations of magnesium ions induce the formation of a unitary protein scaffold, whereas low magnesium concentration leads to a binary protein scaffold. The molecular interactions in the protein scaffold were characterized with X-ray crystallography to high resolution. We show that the unitary framework can be applied for the assembly of inorganic nanoparticles such as metal oxides into highly ordered bioinorganic structures. Our work emphasizes the structural tunability of protein-container-based materials, important for adjusting emerging properties of such materials. PubMed: 30351078DOI: 10.1021/acs.inorgchem.8b01995 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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