5JKK

Crystal structure of the negatively supercharged variant Ftn(neg) of human heavy chain ferritin

5JKK の概要

• エントリーDOI: 10.2210/pdb5jkk/pdb
• 分子名称: Ferritin heavy chain, FE (III) ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: protein design, protein engineering, charged protein containers, binary protein structures, self-assembly, binary nanoparticle superlattices, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 171886.93

構造登録者

Kuenzle, M.,Beck, T. (登録日: 2016-04-26, 公開日: 2017-05-10, 最終更新日: 2024-01-10)

主引用文献

Kunzle, M.,Eckert, T.,Beck, T.
Metal-Assisted Assembly of Protein Containers Loaded with Inorganic Nanoparticles.
Inorg.Chem., 57:13431-13436, 2018

PubMed Abstract: Protein containers are suitable building blocks for bioinorganic materials. Here, we show that high concentrations of magnesium ions induce the formation of a unitary protein scaffold, whereas low magnesium concentration leads to a binary protein scaffold. The molecular interactions in the protein scaffold were characterized with X-ray crystallography to high resolution. We show that the unitary framework can be applied for the assembly of inorganic nanoparticles such as metal oxides into highly ordered bioinorganic structures. Our work emphasizes the structural tunability of protein-container-based materials, important for adjusting emerging properties of such materials.

PubMed: 30351078
DOI: 10.1021/acs.inorgchem.8b01995

実験手法

X-RAY DIFFRACTION (1.6 Å)