5JKG
The crystal structure of FGFR4 kinase domain in complex with LY2874455
Summary for 5JKG
Entry DOI | 10.2210/pdb5jkg/pdb |
Descriptor | Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol (3 entities in total) |
Functional Keywords | kinase, small-molecule inhibitor, atp binding pocket, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455 |
Total number of polymer chains | 1 |
Total formula weight | 35135.39 |
Authors | |
Primary citation | Wu, D.,Guo, M.,Philips, M.A.,Qu, L.,Jiang, L.,Li, J.,Chen, X.,Chen, Z.,Chen, L.,Chen, Y. Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 Plos One, 11:e0162491-e0162491, 2016 Cited by PubMed: 27618313DOI: 10.1371/journal.pone.0162491 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.352 Å) |
Structure validation
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