5JHR
Yeast 20S proteasome in complex with the peptidic epoxyketone inhibitor 27
Summary for 5JHR
Entry DOI | 10.2210/pdb5jhr/pdb |
Related | 1G65 5CZ4 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, proteasome, inhibitor, binding analysis, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 733095.65 |
Authors | Huber, E.M.,Groll, M. (deposition date: 2016-04-21, release date: 2016-08-03, Last modification date: 2024-01-10) |
Primary citation | Xin, B.T.,de Bruin, G.,Huber, E.M.,Besse, A.,Florea, B.I.,Filippov, D.V.,van der Marel, G.A.,Kisselev, A.F.,van der Stelt, M.,Driessen, C.,Groll, M.,Overkleeft, H.S. Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes. J.Med.Chem., 59:7177-7187, 2016 Cited by PubMed: 27438186DOI: 10.1021/acs.jmedchem.6b00705 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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