5JHH

Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11

5JHH の概要

• エントリーDOI: 10.2210/pdb5jhh/pdb
• 関連するPDBエントリー: 5JHG
• 分子名称: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: rhoa-inhibitor-arhgef11 ternary complex, target-based pharmaceutical design, signaling protein-transcription-inhibitor complex, signaling protein/transcription/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : O15085; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127667.28

構造登録者

Lv, Z.,Wang, R.,Ma, L.,Miao, Q.,Wu, J.,Yan, Z.,Li, J.,Miao, L.,Wang, F. (登録日: 2016-04-21, 公開日: 2017-04-26, 最終更新日: 2024-03-20)

• 主引用文献: Wang, R.,Yan, Z.,Lv, Z.,Ma, L.,Miao, Q.,Chen, Q.,Wang, F.,Li, J.,Miao, L.; Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF; To Be Published,

実験手法

X-RAY DIFFRACTION (2.3 Å)