5JDO

T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin

5JDO の概要

• エントリーDOI: 10.2210/pdb5jdo/pdb
• 分子名称: Haptoglobin-haemoglobin receptor, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... (8 entities in total)
• 機能のキーワード: trypanosome, haptoglobin-haemoglobin receptor, haemoglobin, epimastigote, oxygen transport
• 由来する生物種: Trypanosoma congolense; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 116862.13

構造登録者

Lane-Serff, H.,Higgins, M.K. (登録日: 2016-04-17, 公開日: 2016-04-27, 最終更新日: 2024-11-06)

主引用文献

Lane-Serff, H.,MacGregor, P.,Peacock, L.,Macleod, O.J.,Kay, C.,Gibson, W.,Higgins, M.K.,Carrington, M.
Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.
Elife, 5:-, 2016

PubMed Abstract: The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense receptor in complex with haemoglobin. This allows us to propose an evolutionary history for this receptor, charting the structural and cellular changes that took place as it adapted from a role in the insect to a new role in the mammalian host.

PubMed: 27083048
DOI: 10.7554/eLife.13044

実験手法

X-RAY DIFFRACTION (3.2 Å)