5JCX

Trypanosoma brucei PTR1 in complex with inhibitor NP-29

Summary for 5JCX

• Entry DOI: 10.2210/pdb5jcx/pdb
• Related: 5JCJ
• Descriptor: Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one, ... (6 entities in total)
• Functional Keywords: trypanosoma brucei, pteridine reductase, oxydoreductase, inhibitor, oxidoreductase
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 4
• Total formula weight: 126219.38

Authors

Landi, G.,Pozzi, C.,Di Pisa, F.,Dello Iacono, L.,Mangani, S. (deposition date: 2016-04-15, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Borsari, C.,Luciani, R.,Pozzi, C.,Poehner, I.,Henrich, S.,Trande, M.,Cordeiro-da-Silva, A.,Santarem, N.,Baptista, C.,Tait, A.,Di Pisa, F.,Dello Iacono, L.,Landi, G.,Gul, S.,Wolf, M.,Kuzikov, M.,Ellinger, B.,Reinshagen, J.,Witt, G.,Gribbon, P.,Kohler, M.,Keminer, O.,Behrens, B.,Costantino, L.,Tejera Nevado, P.,Bifeld, E.,Eick, J.,Clos, J.,Torrado, J.,Jimenez-Anton, M.D.,Corral, M.J.,Alunda, J.M.,Pellati, F.,Wade, R.C.,Ferrari, S.,Mangani, S.,Costi, M.P.; Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.; J.Med.Chem., 59:7598-7616, 2016; PubMed: 27411733; DOI: 10.1021/acs.jmedchem.6b00698

Experimental method

X-RAY DIFFRACTION (1.43 Å)