5JCX
Trypanosoma brucei PTR1 in complex with inhibitor NP-29
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0047040 | molecular_function | pteridine reductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0047040 | molecular_function | pteridine reductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0047040 | molecular_function | pteridine reductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0047040 | molecular_function | pteridine reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NAP A 301 |
| Chain | Residue |
| A | ARG14 |
| A | THR64 |
| A | ASN93 |
| A | ALA94 |
| A | SER95 |
| A | THR126 |
| A | LEU159 |
| A | CYS160 |
| A | TYR174 |
| A | LYS178 |
| A | PRO204 |
| A | ILE15 |
| A | GLY205 |
| A | SER207 |
| A | LEU208 |
| A | CC6302 |
| A | HOH416 |
| A | HOH417 |
| A | HOH422 |
| A | HOH432 |
| A | HOH457 |
| A | HOH512 |
| A | TYR34 |
| A | HOH520 |
| A | HOH537 |
| A | HOH542 |
| A | HIS35 |
| A | ASN36 |
| A | SER37 |
| A | ALA61 |
| A | ASP62 |
| A | LEU63 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue CC6 A 302 |
| Chain | Residue |
| A | ARG14 |
| A | PHE97 |
| A | ASP161 |
| A | CSX168 |
| A | TYR174 |
| A | VAL206 |
| A | PRO210 |
| A | MET213 |
| A | TRP221 |
| A | NAP301 |
| A | HOH401 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 303 |
| Chain | Residue |
| A | LYS13 |
| A | ARG14 |
| A | ARG17 |
| A | HOH406 |
| A | HOH424 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 304 |
| Chain | Residue |
| A | PHE243 |
| A | SER246 |
| A | SER248 |
| A | HOH462 |
| A | HOH513 |
| A | HOH521 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | GLU215 |
| A | LYS218 |
| A | ARG222 |
| A | HOH410 |
| site_id | AC6 |
| Number of Residues | 34 |
| Details | binding site for residue NAP B 301 |
| Chain | Residue |
| B | ARG14 |
| B | ILE15 |
| B | HIS33 |
| B | TYR34 |
| B | HIS35 |
| B | ASN36 |
| B | SER37 |
| B | ALA61 |
| B | ASP62 |
| B | LEU63 |
| B | THR64 |
| B | ASN93 |
| B | ALA94 |
| B | SER95 |
| B | THR126 |
| B | LEU159 |
| B | CYS160 |
| B | ASP161 |
| B | TYR174 |
| B | LYS178 |
| B | PRO204 |
| B | GLY205 |
| B | SER207 |
| B | LEU208 |
| B | CC6302 |
| B | HOH405 |
| B | HOH429 |
| B | HOH434 |
| B | HOH440 |
| B | HOH442 |
| B | HOH512 |
| B | HOH541 |
| B | HOH550 |
| B | HOH556 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue CC6 B 302 |
| Chain | Residue |
| B | TRP221 |
| B | NAP301 |
| B | HOH401 |
| B | ARG14 |
| B | PHE97 |
| B | ASP161 |
| B | TYR174 |
| B | VAL206 |
| B | PRO210 |
| B | MET213 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 301 |
| Chain | Residue |
| B | TYR34 |
| B | VAL58 |
| C | VAL57 |
| C | VAL58 |
| C | HOH412 |
| C | HOH504 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue ACT C 302 |
| Chain | Residue |
| B | ALA45 |
| B | ASP46 |
| C | TYR34 |
| C | CYS59 |
| C | GLN60 |
| C | HOH401 |
| C | HOH407 |
| C | HOH443 |
| site_id | AD1 |
| Number of Residues | 30 |
| Details | binding site for residue NAP D 301 |
| Chain | Residue |
| D | ARG14 |
| D | ILE15 |
| D | TYR34 |
| D | HIS35 |
| D | ASN36 |
| D | SER37 |
| D | ALA61 |
| D | ASP62 |
| D | LEU63 |
| D | THR64 |
| D | ASN93 |
| D | ALA94 |
| D | SER95 |
| D | THR126 |
| D | LEU159 |
| D | CYS160 |
| D | ASP161 |
| D | TYR174 |
| D | LYS178 |
| D | PRO204 |
| D | GLY205 |
| D | SER207 |
| D | LEU208 |
| D | CC6302 |
| D | HOH404 |
| D | HOH412 |
| D | HOH416 |
| D | HOH438 |
| D | HOH448 |
| D | HOH501 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue CC6 D 302 |
| Chain | Residue |
| D | ARG14 |
| D | PHE97 |
| D | ASP161 |
| D | TYR174 |
| D | VAL206 |
| D | LEU209 |
| D | PRO210 |
| D | MET213 |
| D | TRP221 |
| D | NAP301 |
| D | HOH401 |
| D | HOH526 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 303 |
| Chain | Residue |
| D | PHE243 |
| D | SER246 |
| D | SER248 |
| D | HOH464 |
| D | HOH494 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamvdqpcmaFslYNMGKHALvGLTqSAA |
| Chain | Residue | Details |
| A | ASP161-ALA189 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| A | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | LYS178 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| B | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| B | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | LYS178 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| C | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| C | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | LYS178 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 237 |
| Chain | Residue | Details |
| D | ARG14 | electrostatic stabiliser, hydrogen bond donor, steric role |
| D | ASP161 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | LYS178 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
