5JBQ

EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG

Summary for 5JBQ

• Entry DOI: 10.2210/pdb5jbq/pdb
• Descriptor: Elongation factor Tu 1, THIOMURACIN ANALOG, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: natural product inhibitor, elongation factor, rna binding protein-antimicrobial complex, rna binding protein/antimicrobial
• Biological source: Escherichia coli (strain K12); More
• Cellular location: Cytoplasm: P0CE47
• Total number of polymer chains: 2
• Total formula weight: 45432.04

Authors

Palestrant, D.,Stams, T. (deposition date: 2016-04-13, release date: 2016-07-13, Last modification date: 2023-11-15)

• Primary citation: LaMarche, M.J.,Leeds, J.A.,Brewer, J.,Dean, K.,Ding, J.,Dzink-Fox, J.,Gamber, G.,Jain, A.,Kerrigan, R.,Krastel, P.,Lee, K.,Lombardo, F.,McKenney, D.,Neckermann, G.,Osborne, C.,Palestrant, D.,Patane, M.A.,Rann, E.M.,Robinson, Z.,Schmitt, E.,Stams, T.,Tiamfook, S.,Yu, D.,Whitehead, L.; Antibacterial and Solubility Optimization of Thiomuracin A.; J.Med.Chem., 59:6920-6928, 2016; PubMed: 27355833; DOI: 10.1021/acs.jmedchem.6b00726

Experimental method

X-RAY DIFFRACTION (2.006 Å)