5JA3
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
5JA3 の概要
エントリーDOI | 10.2210/pdb5ja3/pdb |
分子名称 | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (4 entities in total) |
機能のキーワード | dhfr, antifolate, folate pathway, oxidoreductase |
由来する生物種 | Mycobacterium tuberculosis |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 75235.44 |
構造登録者 | |
主引用文献 | Hajian, B.,Scocchera, E.,Keshipeddy, S.,G-Dayanandan, N.,Shoen, C.,Krucinska, J.,Reeve, S.,Cynamon, M.,Anderson, A.C.,Wright, D.L. Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. Plos One, 11:e0161740-e0161740, 2016 Cited by PubMed: 27580226DOI: 10.1371/journal.pone.0161740 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.814 Å) |
構造検証レポート
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