5JA3

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)

5JA3 の概要

• エントリーDOI: 10.2210/pdb5ja3/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: dhfr, antifolate, folate pathway, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75235.44

構造登録者

Hajian, B.,Anderson, A.C. (登録日: 2016-04-11, 公開日: 2016-08-24, 最終更新日: 2024-03-06)

• 主引用文献: Hajian, B.,Scocchera, E.,Keshipeddy, S.,G-Dayanandan, N.,Shoen, C.,Krucinska, J.,Reeve, S.,Cynamon, M.,Anderson, A.C.,Wright, D.L.; Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.; Plos One, 11:e0161740-e0161740, 2016; PubMed: 27580226; DOI: 10.1371/journal.pone.0161740

実験手法

X-RAY DIFFRACTION (1.814 Å)