5J9Y

EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b

Summary for 5J9Y

Entry DOI	10.2210/pdb5j9y/pdb
Descriptor	Epidermal growth factor receptor, (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (3 entities in total)
Functional Keywords	tyrosine kinase, covalent inhibitor, drug resistance, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37362.32
Authors	Becker, C.,Engel, J.,Rauh, D. (deposition date: 2016-04-11, release date: 2016-08-17, Last modification date: 2016-09-07)
Primary citation	Engel, J.,Becker, C.,Lategahn, J.,Keul, M.,Ketzer, J.,Muhlenberg, T.,Kollipara, L.,Schultz-Fademrecht, C.,Zahedi, R.P.,Bauer, S.,Rauh, D. Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR. Angew.Chem.Int.Ed.Engl., 55:10909-10912, 2016 Cited by PubMed: 27496389 DOI: 10.1002/anie.201605011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation