5J9Y
EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 323 | 36963.9 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | non-polymer | 398.5 | 1 | Chemie (6HL) | |||
| 3 | C (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 697 - 1019 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36963.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 398.5 | |
| All* | Total formula weight | 37362.3 |
