5J6S

Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand

5J6S の概要

• エントリーDOI: 10.2210/pdb5j6s/pdb
• 分子名称: Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: endoplasmic reticulum, aminopeptidase, hydrolase, zn binding metallopeptidase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 229256.31

構造登録者

Saridakis, E.,Giastas, P.,Mpakali, A.,Deprez-Poulain, R.,Stratikos, E. (登録日: 2016-04-05, 公開日: 2017-03-15, 最終更新日: 2024-01-10)

• 主引用文献: Mpakali, A.,Giastas, P.,Deprez-Poulain, R.,Papakyriakou, A.,Koumantou, D.,Gealageas, R.,Tsoukalidou, S.,Vourloumis, D.,Mavridis, I.M.,Stratikos, E.,Saridakis, E.; Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.; ACS Med Chem Lett, 8:333-337, 2017; PubMed: 28337326; DOI: 10.1021/acsmedchemlett.6b00505

実験手法

X-RAY DIFFRACTION (2.8 Å)