5J2P

HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site

Summary for 5J2P

• Entry DOI: 10.2210/pdb5j2p/pdb
• Related: 5J2M 5J2N 5J2Q
• Descriptor: reverse transcriptase, p66 domain, reverse transcriptase, p51 domain, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3'), ... (7 entities in total)
• Functional Keywords: hiv-1, reverse transcriptase, rt, dna, double stranded dna, dsdna, efda, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, efda-monophosphate, efda-mp, inhibitors, nrti, tdrti, translocation defective, p site, n site, pre-translocation, post-translocation, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1); More
• Total number of polymer chains: 4
• Total formula weight: 131945.55

Authors

Salie, Z.L.,Kirby, K.A.,Sarafianos, S.G. (deposition date: 2016-03-29, release date: 2016-08-03, Last modification date: 2023-09-27)

• Primary citation: Salie, Z.L.,Kirby, K.A.,Michailidis, E.,Marchand, B.,Singh, K.,Rohan, L.C.,Kodama, E.N.,Mitsuya, H.,Parniak, M.A.,Sarafianos, S.G.; Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).; Proc.Natl.Acad.Sci.USA, 113:9274-9279, 2016; PubMed: 27489345; DOI: 10.1073/pnas.1605223113

Experimental method

X-RAY DIFFRACTION (2.53 Å)