5J2P

HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and a second EFdA-MP at the N-(pre-translocation) site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	reverse transcriptase, p66 domain	polymer	560	64521.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
2	B (B)	reverse transcriptase, p51 domain	polymer	440	51383.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
3	C (P)	DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3')	polymer	22	6871.5	1		Human immunodeficiency virus 1
4	D (T)	DNA (27-MER)	polymer	27	8398.4	1		Human immunodeficiency virus 1
5	E (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	F, G (P)	2'-deoxy-4'-ethynyl-2-fluoroadenosine 5'-(dihydrogen phosphate)	non-polymer		373.2	2	Chemie (6FM)
7	H, I, J, K (A, B, P, T)	water	water		18.0	420	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Cys 258	Gln 845	engineered mutation
Ser 280	Cys 867	engineered mutation

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Ser 280	Cys 867	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131174.8
Non-Polymers*	Number of molecules	3
	Total formula weight	770.8
All*	Total formula weight	131945.5

*Water molecules are not included.