5J2M
HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor
Summary for 5J2M
Entry DOI | 10.2210/pdb5j2m/pdb |
Related | 5J2N 5J2P 5J2Q |
Descriptor | HIV-1 reverse transcriptase p51 subunit, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), DNA (27-MER), ... (7 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, rt, dna, double stranded dna, dsdna, efda, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, efda-triphosphate, efda-tp, inhibitors, nrti, tdrti, translocation defective, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 131384.64 |
Authors | Salie, Z.L.,Kirby, K.A.,Sarafianos, S.G. (deposition date: 2016-03-29, release date: 2016-08-03, Last modification date: 2023-09-27) |
Primary citation | Salie, Z.L.,Kirby, K.A.,Michailidis, E.,Marchand, B.,Singh, K.,Rohan, L.C.,Kodama, E.N.,Mitsuya, H.,Parniak, M.A.,Sarafianos, S.G. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proc.Natl.Acad.Sci.USA, 113:9274-9279, 2016 Cited by PubMed: 27489345DOI: 10.1073/pnas.1605223113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.432 Å) |
Structure validation
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