5J2M

HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HIV-1 reverse transcriptase p51 subunit	polymer	560	64521.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
2	B	HIV-1 reverse transcriptase p51 subunit	polymer	440	51383.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
3	P	DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3')	polymer	21	6490.3	1		Human immunodeficiency virus 1
4	T	DNA (27-MER)	polymer	27	8383.4	1		Human immunodeficiency virus 1
5	A	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
6	A	2'-deoxy-4'-ethynyl-2-fluoroadenosine 5'-(tetrahydrogen triphosphate)	non-polymer		533.2	1	Chemie (6FN)
7		water	water		18.0	384	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Cys 258	Gln 845	engineered mutation
Ser 280	Cys 867	engineered mutation

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Ser 280	Cys 867	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130778.5
Non-Polymers*	Number of molecules	4
	Total formula weight	606.1
All*	Total formula weight	131384.6

*Water molecules are not included.