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5IXC

Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate

Summary for 5IXC
Entry DOI10.2210/pdb5ixc/pdb
Related5IZ5
DescriptorCytosolic phospholipase A2 delta, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate, BARIUM ION, ... (4 entities in total)
Functional Keywordsinhibitor, signal transduction, phospholipase, alpha/beta hydrolase, calcium binding, c2 domain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol: Q86XP0
Total number of polymer chains2
Total formula weight184401.46
Authors
Wang, H.,Klein, M.G. (deposition date: 2016-03-23, release date: 2016-06-08, Last modification date: 2023-09-27)
Primary citationWang, H.,Klein, M.G.,Snell, G.,Lane, W.,Zou, H.,Levin, I.,Li, K.,Sang, B.C.
Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
J.Mol.Biol., 428:2769-2779, 2016
Cited by
PubMed: 27220631
DOI: 10.1016/j.jmb.2016.05.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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