5IV3

Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1

Summary for 5IV3

Entry DOI	10.2210/pdb5iv3/pdb
Descriptor	Adenylate cyclase type 10, ACETATE ION, GLYCEROL, ... (10 entities in total)
Functional Keywords	human soluble adenylyl cyclase hsac complex alpha, beta-methyleneadenosine-5'-triphosphate, allosteric inhibitor lre1, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q96PN6
Total number of polymer chains	1
Total formula weight	55693.74
Authors	Kleinboelting, S.,Steegborn, C. (deposition date: 2016-03-18, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Ramos-Espiritu, L.,Kleinboelting, S.,Navarrete, F.A.,Alvau, A.,Visconti, P.E.,Valsecchi, F.,Starkov, A.,Manfredi, G.,Buck, H.,Adura, C.,Zippin, J.H.,van den Heuvel, J.,Glickman, J.F.,Steegborn, C.,Levin, L.R.,Buck, J. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12:838-844, 2016 Cited by PubMed: 27547922 DOI: 10.1038/nchembio.2151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation