5IV0

Crystal structure of Eis from Mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme A

Summary for 5IV0

Entry DOI	10.2210/pdb5iv0/pdb
Descriptor	Enhanced intracellular survival protein, COENZYME A, N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide, ... (5 entities in total)
Functional Keywords	transferase, acetyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Total number of polymer chains	1
Total formula weight	47896.10
Authors	Gajadeera, C.S.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2016-03-18, release date: 2017-01-11, Last modification date: 2024-03-06)
Primary citation	Garzan, A.,Willby, M.J.,Green, K.D.,Gajadeera, C.S.,Hou, C.,Tsodikov, O.V.,Posey, J.E.,Garneau-Tsodikova, S. Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis. J. Med. Chem., 59:10619-10628, 2016 Cited by PubMed: 27933949 DOI: 10.1021/acs.jmedchem.6b01161 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation