5IV0
Crystal structure of Eis from Mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Enhanced intracellular survival protein | polymer | 428 | 46660.8 | 1 | UniProt (P9WFK6) Pfam (PF13527) Pfam (PF17668) Pfam (PF13530) UniProt (by SIFTS) (P9WFK7) In PDB | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | |
2 | A | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
3 | A | N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide | non-polymer | 361.4 | 1 | Chemie (6E9) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
5 | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A: -5 - 402 (UniProt: P9WFK6)
PDB | External Database | Details |
---|---|---|
Met -25 | - | initiating methionine |
Gly -24 | - | expression tag |
Ser -23 | - | expression tag |
Ser -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
Ser -15 | - | expression tag |
Ser -14 | - | expression tag |
Gly -13 | - | expression tag |
Leu -12 | - | expression tag |
Val -11 | - | expression tag |
Pro -10 | - | expression tag |
Arg -9 | - | expression tag |
Gly -8 | - | expression tag |
Ser -7 | - | expression tag |
His -6 | - | expression tag |
Leu -4 | Pro 2 | SEE REMARK 999 |
Met 1 | Val 7 | SEE REMARK 999 |
Ala 204 | Cys 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 46660.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1235.3 | |
All* | Total formula weight | 47896.1 |