5IV0
Crystal structure of Eis from Mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Enhanced intracellular survival protein | polymer | 428 | 46660.8 | 1 | UniProt (P9WFK6) Pfam (PF13527) Pfam (PF17668) Pfam (PF13530) UniProt (by SIFTS) (P9WFK7) | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | |
| 2 | B (A) | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
| 3 | C (A) | N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide | non-polymer | 361.4 | 1 | Chemie (6E9) | |||
| 4 | D, E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | G (A) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A: -5 - 402 (UniProt: P9WFK6)
| PDB | External Database | Details |
|---|---|---|
| Met -25 | - | initiating methionine |
| Gly -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Ser -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Val -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Arg -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| Leu -4 | Pro 2 | SEE REMARK 999 |
| Met 1 | Val 7 | SEE REMARK 999 |
| Ala 204 | Cys 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46660.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1235.3 | |
| All* | Total formula weight | 47896.1 |
