5IUH
Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d
Summary for 5IUH
Entry DOI | 10.2210/pdb5iuh/pdb |
Related | 5IUG 5IUI |
Descriptor | ALK tyrosine kinase receptor, 4-[(4-methylpiperazin-1-yl)methyl]-N-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1H-pyrazol-5-yl}benzamide (3 entities in total) |
Functional Keywords | catalytic domain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 37389.86 |
Authors | |
Primary citation | Tu, C.H.,Lin, W.H.,Peng, Y.H.,Hsu, T.,Wu, J.S.,Chang, C.Y.,Lu, C.T.,Lyu, P.C.,Shih, C.,Jiaang, W.T.,Wu, S.Y. Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK). J.Med.Chem., 59:3906-3919, 2016 Cited by PubMed: 27031565DOI: 10.1021/acs.jmedchem.6b00106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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