5IUG

Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a

Summary for 5IUG

• Entry DOI: 10.2210/pdb5iug/pdb
• Related: 5IUH 5IUI
• Descriptor: ALK tyrosine kinase receptor, N-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide (3 entities in total)
• Functional Keywords: catalytic domain, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37403.89

Authors

Tu, C.H.,Wu, S.Y. (deposition date: 2016-03-18, release date: 2016-05-18, Last modification date: 2024-03-20)

• Primary citation: Tu, C.H.,Lin, W.H.,Peng, Y.H.,Hsu, T.,Wu, J.S.,Chang, C.Y.,Lu, C.T.,Lyu, P.C.,Shih, C.,Jiaang, W.T.,Wu, S.Y.; Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).; J.Med.Chem., 59:3906-3919, 2016; PubMed: 27031565; DOI: 10.1021/acs.jmedchem.6b00106

Experimental method

X-RAY DIFFRACTION (1.93 Å)