5ITA

Crystal Structure of BRAF Kinase Domain Bound to AZ-VEM

Summary for 5ITA

• Entry DOI: 10.2210/pdb5ita/pdb
• Related: 4RZV 4RZW 5ISS
• Descriptor: Serine/threonine-protein kinase B-raf, N-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide (3 entities in total)
• Functional Keywords: transferase, kinase and inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 68258.21

Authors

Wu, Y.,Gavathiotis, E. (deposition date: 2016-03-16, release date: 2016-08-10, Last modification date: 2023-09-27)

• Primary citation: Karoulia, Z.,Wu, Y.,Ahmed, T.A.,Qisheng, X.,Bollard, J.,Krepler, C.,Wu, X.,Zhang, C.,Bollag, G.,Herlym, M.,Fagin, J.A.,Lujambio, A.,Gavathiotis, E.,Poulikakos, P.I.; An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling; Cancer Cell, 30:1-14, 2016

Experimental method

X-RAY DIFFRACTION (1.95 Å)