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5ITA

Crystal Structure of BRAF Kinase Domain Bound to AZ-VEM

Summary for 5ITA
Entry DOI10.2210/pdb5ita/pdb
Related4RZV 4RZW 5ISS
DescriptorSerine/threonine-protein kinase B-raf, N-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide (3 entities in total)
Functional Keywordstransferase, kinase and inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P15056
Total number of polymer chains2
Total formula weight68258.21
Authors
Wu, Y.,Gavathiotis, E. (deposition date: 2016-03-16, release date: 2016-08-10, Last modification date: 2023-09-27)
Primary citationKaroulia, Z.,Wu, Y.,Ahmed, T.A.,Qisheng, X.,Bollard, J.,Krepler, C.,Wu, X.,Zhang, C.,Bollag, G.,Herlym, M.,Fagin, J.A.,Lujambio, A.,Gavathiotis, E.,Poulikakos, P.I.
An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling
Cancer Cell, 30:1-14, 2016
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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