5ISQ
Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase mutant complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
5ISQ の概要
エントリーDOI | 10.2210/pdb5isq/pdb |
関連するPDBエントリー | 5HF0 5HF2 5ISP 5IST |
分子名称 | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (5 entities in total) |
機能のキーワード | oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics |
由来する生物種 | Staphylococcus aureus |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 19625.88 |
構造登録者 | |
主引用文献 | Reeve, S.M.,Scocchera, E.,Ferreira, J.J.,G-Dayanandan, N.,Keshipeddy, S.,Wright, D.L.,Anderson, A.C. Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations. J. Med. Chem., 59:6493-6500, 2016 Cited by PubMed: 27308944DOI: 10.1021/acs.jmedchem.6b00688 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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