5HF0

Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)

Summary for 5HF0

• Entry DOI: 10.2210/pdb5hf0/pdb
• Related: 4XEC 5HF2
• Descriptor: Dihydrofolate reductase, GLYCEROL, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (6 entities in total)
• Functional Keywords: oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 20379.34

Authors

Anderson, A.C.,Reeve, S.M. (deposition date: 2016-01-06, release date: 2017-01-18, Last modification date: 2024-03-06)

• Primary citation: Anderson, A.C.,Reeve, S.M.; Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1106); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.245 Å)