5HF2

Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175)

Summary for 5HF2

• Entry DOI: 10.2210/pdb5hf2/pdb
• Related: 4XEC 5HF0
• Descriptor: Dihydrofolate reductase, Tricyclic NADPH, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ... (5 entities in total)
• Functional Keywords: oxidoreductase, nadph, propargyl-linked antifolates, dihydrofolate reductase, antibiotics
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 19255.52

Authors

Reeve, S.M.,Anderson, A.C. (deposition date: 2016-01-06, release date: 2017-01-18, Last modification date: 2024-03-06)

• Primary citation: Reeve, S.M.,Anderson, A.C.; Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.81 Å)