5ISP

Staphylococcus aureus F98Y Dihydrofolate Reductase mutant complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)

Summary for 5ISP

Entry DOI	10.2210/pdb5isp/pdb
Related	5HF0 5HF2 5ISQ 5IST
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (5 entities in total)
Functional Keywords	oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19649.92
Authors	Anderson, A.C.,Reeve, S.M. (deposition date: 2016-03-15, release date: 2017-06-28, Last modification date: 2024-03-06)
Primary citation	Reeve, S.M.,Scocchera, E.,Ferreira, J.J.,G-Dayanandan, N.,Keshipeddy, S.,Wright, D.L.,Anderson, A.C. Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations. J. Med. Chem., 59:6493-6500, 2016 Cited by PubMed: 27308944 DOI: 10.1021/acs.jmedchem.6b00688 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation