5ISP
Staphylococcus aureus F98Y Dihydrofolate Reductase mutant complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | X | Dihydrofolate reductase | polymer | 160 | 18412.0 | 1 | UniProt (P0A017) Pfam (PF00186) In PDB | Staphylococcus aureus | DHFR |
2 | X | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | X | 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid | non-polymer | 402.4 | 1 | Chemie (U06) | |||
4 | X | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
X: 1 - 157 (UniProt: P0A017)
PDB | External Database | Details |
---|---|---|
Tyr 98 | Phe 99 | engineered mutation |
Leu 158 | - | expression tag |
Glu 159 | - | expression tag |
His 160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18412.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1237.9 | |
All* | Total formula weight | 19649.9 |